RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-101a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qPCR; dual-luciferase reporter assay etc.
Target
TGFBR1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-101a suppresses fibrotic programming in isolated cardiac fibroblasts and in vivo fibrosis following trans-aortic constriction
Year
2018
Function
"miR-101a, introduced early after imposition of abnormal pressure loading, inhibits TGF-beta signaling, reduces cardiac fibrosis and preserves Left ventricular (LV) function."